Senior Fellow
Education
PhD Oral Biology, University of Washington
Research Interests
- The oral microbiome
- Host immune responses to oral polymicrobial interactions
Publications
Bor B, McLean JS, Foster KR, Cen L, To TT, Serrato-Guillen A, Dewhirst FE, Shi W, He X. Rapid evolution of decreased host susceptibility drives a stable relationship between ultrasmall parasite TM7x and its bacterial host. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12277-12282. doi: 10.1073/pnas.1810625115. Epub 2018 Nov 15. PubMed PMID: 30442671
Kajiwara K, Takata S, To TT, et al. The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors. Diabetol Metab Syndr. 2017;9(1):73.
Hanson-Drury SR, To TT, Liu Q, Vo AT, Kim M, Watling M, Bumgarner RB, McLean JS. Draft genome sequence of Tannerella forsythia 9610. Genome Announcement. 2017;5(12):16-17.
Coats SR, Hashim A, Paramanov N, To TT, Curtis MA, Darveau RP. Cardiolipins Act as a Selective Barrier to Toll-Like Receptor 4 Activation in the Intestine. Appl Environ Microbiol. 2016 Jun 30; 82(14). PMCID: PMC4959216
To TT, Liu Q, Watling M, Darveau RP, Bumgarner RE, McLean JS. Genome sequence of low-passage clinical isolate Porphyromonas gingivalis MP4-504. Genome Announc. 2016 Apr 7; 4(2). PMID: 27056232
Edlund AE, Liu Q, Lux RE, Watling M, To TT, Bumgarner RE, He X, Shi W, McLean JS. High quality draft genome of low pH active Veilonella parvula strain SHI-1 isolated from human saliva within an in vitro oral biofilm model. Genome Announc. 2016; 4(1). PMID: 26894319
McLean JS, Liu Q, Bor B, Bedree JK, Lujia C, Watling M, To TT, Bumgarner RE, He X, Shi W. Draft genome of Actinomyces odontolyticus subsp. actinosynbacter strain XH001 the basibiont of an oral TM7 epibiont. Genome Announc. 2016; 4(1). PMID: 26847892.
To TT, Gumus P, Nizam N, Buduneli N, Darveau RP. Subgingival plaque in periodontal health antagonizes at TLR4 and inhibits E-selectin expression on endothelial cells. Infect Immun. 2016; 84(1):120-126. PMCID: 26483407.
Chilton PM, Hadel DM, To TT , Mitchell TC, Darveau RP. Adjuvant activity of naturally-occurring monophosphoryl lipid A preparations from mucosal-niche bacteria. Infect Immun. 2013; 81(9):3317-25. PMCID: 3754217.
Coats SR, Berezow AB, To TT, Jain S, Bainbridge BW, Banani KP, Darveau RP. The lipid A phosphate position determines differential host Toll-like receptor 4 responses to phylogenetically related symbiotic and pathogenic bacteria. Infect Immun. 2011;79(1):203-10. PMCID: 3019871.
Coats SR, To TT, Jain S, Braham PH, Darveau RP. Porphyromonas gingivalis resistance to polymyxin B is determined by the lipid A 4′-phosphatase, PGN_0524. Int J Oral Sci. 2009;1(3):126-35. PMCID: 2909122.
Coats SR, Jones JW, Do CT, Braham PH, Bainbridge BW, To TT, Goodlett DR, Ernst RK, Darveau RP. Human Toll-like receptor 4 responses to P. gingivalis are regulated by lipid A 1- and 4′-phosphatase activities. Cell Microbiol. 2009;11(11):1587-99. PMCID: 3074576.
Contact
Address:
1959 NE Pacific St
Box 357444
Seattle, WA 98195-7444
Phone: 206-616-2614
Email: thao2 [at] uw.edu