Immune-regulating drug improves gum disease in mice
Date: April 28, 2020
Jonathan Y An, Kristopher A Kerns, Andrew Ouellette, Laura Robinson, H Douglas Morris, Catherine Kaczorowski, So-Il Park, Title Mekvanich, Alex Kang, Jeffrey S McLean, Timothy C Cox, Matt Kaeberlein. Rapamycin rejuvenates oral health in aging mice. eLife, 2020; 9
Our Oral Microbiome Metabolomics work led by Anna Edlund (JCVI) in Collaboration with Pieter Dorrestein (UCSD) using GNPS . Metabolic fingerprints from the human oral microbiome reveal a vast knowledge gap of secreted small peptidic molecules.
Meet Your Microbes! June 2015 – December 2015
There are trillions of organisms living in and on your body. And it’s OK. In Meet your Microbes! learn about the microscopic organisms that help you digest food, process vitamins, protect you from infection or even, sometimes, make you sick.
The TWiM cohort discusses the use of antimicrobial peptides to target specific bacteria in the microbiome, and how the intracellular bacterium Wolbachia selectively kills male hosts.
Guo, L., J. S. McLean, Y. Yang, R. Eckert, C. W. Kaplan, P. Kyme, O. Sheikh, B. Varnum, R. Lux, W. Shi and X. He (2015). “Precision-guided antimicrobial peptide as a targeted modulator of human microbial ecology.”
Meta-Omics Uncover Temporal Regulation of Pathways Across Oral Microbiome Genera During in vitro Sugar Metabolism. (2105) International Society for Microbial Ecology Journal (ISME).