May 21, 2020

Rapamycin rejuvenates oral health and younger oral microbiome in aging mice.

Science News Immune-regulating drug improves gum disease in mice Date: April 28, 2020 https://www.sciencedaily.com/releases/2020/04/200428112540.htm Jonathan Y An, Kristopher A Kerns, Andrew Ouellette, Laura Robinson, H Douglas Morris, Catherine Kaczorowski, So-Il Park, Title Mekvanich, Alex Kang, Jeffrey S McLean, Timothy C Cox, Matt Kaeberlein. Rapamycin rejuvenates oral health in aging mice. eLife, 2020; 9 https://elifesciences.org/articles/54318  Read more...


March 21, 2019

A Review of Saccharibacteria (TM7) in the Human Oral Microbiome

A Review of Saccharibacteria (TM7) in the Human Oral Microbiome 3/21/19 The recent cultivation and characterization of Nanosynbacter lyticus type strain TM7x (HMT_952)—the first Saccharibacteria strain co-isolated as an ultra-small obligate parasite with its bacterial host from the human oral cavity—provide a rare glimpse into the novel symbiotic lifestyle of these enigmatic human-associated bacteria. TM7x is unique…  Read more...


UW researchers help take major step in study of elusive bacteria

UW researchers help take major step in study of elusive bacteria 12/4/18 Two University of Washington researchers and their colleagues have helped take a significant step forward in the study of especially tiny bacteria that may be linked to gum disease. Dr. Jeffrey McLean Dr. Jeffrey McLean and Dr. Thao (Jenny) To of the UW…  Read more...


December 6, 2018

UW researchers help take major step in study of elusive bacteria

12/4/2018 Two University of Washington researchers and their colleagues have helped take a significant step forward in the study of especially tiny bacteria that may be linked to gum disease. Dr. Jeffrey McLean Dr. Jeffrey McLean and Dr. Thao (Jenny) To of the UW School of Dentistry and their cohorts at the Forsyth Institute in…  Read more...


July 19, 2017

Metabolic fingerprints from the human oral microbiome

Our Oral Microbiome Metabolomics work led by Anna Edlund (JCVI) in Collaboration with Pieter Dorrestein (UCSD) using GNPS . Metabolic fingerprints from the human oral microbiome reveal a vast knowledge gap of secreted small peptidic molecules.   Read more...


September 7, 2016

ScienceNews Article: Microbial matter comes out of the dark

ScienceNews  Read more...


August 10, 2016

Collaborator Publication: Nature Biotechnology Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

Nature  Read more...


October 28, 2015

Contribution to Microbiome Exhibit in Pacific Science Center

Meet Your Microbes! June 2015 – December 2015

There are trillions of organisms living in and on your body. And it’s OK. In Meet your Microbes! learn about the microscopic organisms that help you digest food, process vitamins, protect you from infection or even, sometimes, make you sick.  Read more...


August 13, 2015

Coverage of our Recent work in “This Week in Microbiology”

The TWiM cohort discusses the use of antimicrobial peptides to target specific bacteria in the microbiome, and how the intracellular bacterium Wolbachia selectively kills male hosts.  Read more...


June 3, 2015

Killing Streptococcus mutans and modulating the oral microbiome with a precision guided antimicrobial peptide

Guo, L., J. S. McLean, Y. Yang, R. Eckert, C. W. Kaplan, P. Kyme, O. Sheikh, B. Varnum, R. Lux, W. Shi and X. He (2015). “Precision-guided antimicrobial peptide as a targeted modulator of human microbial ecology.”  Read more...


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