Research

Active Support

Domestication and Characterization of TM7-The Most Elusive Oral Phylum

NIH/NIDCR

The major goal of this project is to study the ecology, evolution and pathogenesis of human oral phlyum TM7 (Saccharibacteria) that our group has cultivated. The Saccharibacteria are now recognized as part of the Candidate Phyla Radiation and our cultivated strain TM7x  was the first and only member of this large group that comprises nearly 25% of the diversity in the Domain Bacteria.

 

Making a Quantum Leap in Plaque Research with Modern Sciences

NIH/NIDCR

The major goals of this project are the development of new tools to study the etiology of dental caries, explore approaches for targeted elimination of cariogenic species and examine the effect on acid-production of the dental biofilm community.

 

Studying the Protective Effects of Normal Oral Flora

NIH/NIDCR

The major goal of this project is to study how normal flora can work together in a coordinated manner to prevent harmful ones from establishing themselves in our body.

 

Systematic Approach to Explore the Microbial Interactome 

NIH/NIDCR

Research in this grant will seek to provide a versatile approach for comprehensive investigation of the microbial interactome.

 

Completed Support

Moving Beyond Diversity by Revealing Biological Functions of Uncultured Bacteria

NIH/NIGMS

We will investigate oral microbiome communities seeking to identify the species and genes that are highly correlated with microbial processes in disease state through parallel metabolomics and metatranscriptomics.

 

Award Details


Active As PI :

 

  1. Agency: NIH R01, National Institute of Dental and Craniofacial Research

Title: Domestication and characterization of TM7-the most elusive oral phylum

Date: 04/01/2014 – 12/31/23

PI: Jeffrey S. McLean (Multiple PI Award)

 

 

  1. Agency: NIH R01, National Institute of Dental and Craniofacial Research

Title: Making a Quantum Leap in Plaque Research with Modern Sciences

Date: 5/1/2010-12/31/2020

PI: Jeffrey S. McLean (Multiple PI Award)

 

  1. Agency: NIH R01, National Institute of Dental and Craniofacial Research

Title: Exploring the Protective Effects of Normal Oral Flora Against Foreign Pathogens

Date: 7/1/2016-6/30/2021

PI: Jeffrey S. McLean (Multiple PI Award)

 

  1. Agency: NIH R01, National Institute of Dental and Craniofacial Research

Title: 1R21DE027199-01 Systematic Approach to Explore the Microbial Interactome

Date: 7/1/2017-6/30/2019

PI: Jeffrey S McLean (Multiple PI Award)

 

Completed Grants:

Completed

Funded Grants as PI

Agency: NIH R01, National Institute of General Medical Sciences

Title: Moving Beyond Diversity by Revealing Biological Functions of Uncultured Bacteria

Date: 12/01/10-11/30/14         (NCE 2016)

PI: Jeffrey S. McLean

 

Agency: D.O.E.

Title: Microscale Metabolic, Redox and Abiotic Reactions in Hanford 300 Area Subsurface Sediments

Date: 05/15/08-05/14/12

PI: Haluk Beyenal (WSU)

Co-PIs: Jeffrey S. McLean (PNNL) and Jim K. Fredrickson (PNNL)

 

Agency: NIH R21, National Institute of Dental and Craniofacial Research

Title: Combined NMR/Optical Microscopy for Oral Biofilm Physiology Studies

Date: 05/15/07-05/14/10

PI: Paul Majors (PNNL)

Co-PI: Jeffrey S. McLean (PNNL)

 

Agency: D.O.E. OBER’s Genomics:GTL Program

Title: Integrated Genome-Based Studies of Shewanella Ecophysiology

Date: 9/31/06- 9/31/09

PI: J.Fredrickson

Co-PIs: Jeffrey S. McLean (PNNL), 10+ others

 

Agency: D.O.E. Laboratory Directed Research and Development

Title: Controlled Cultivation, Molecular Biology, and Advanced Imaging of Microbial Biofilms

Date: 10/1/04 to 9/31/07

PI: J. McLean

 

Agency: D.O.E. Laboratory Directed Research and Development

Title: Interrogation of Glucose Metabolism by Oral Biofilms Using Combined NMR/Optical Spectroscopy and Stable Isotope Labeling

Date: 10/1/05 to 9/31/07

Co-PI: J. McLean

 

Agency: D.O.E. Laboratory Directed Research and Development

Title: PNNL Metabolomics Measurement and Validation Development for Renewable Energy

Date: 10/1/05 to 9/31/07

Co-PI: J. McLean

 

Agency: D.O.E. Laboratory Directed Research and Development

Title: In Situ Magnetic Resonance Investigations of Metabolism and Mass Transport in Biofilms

Date: 10/1/04 to 9/31/05

Co-PI: J. McLean

 

Agency: D.O.E. Laboratory Directed Research and Development

Title: Mathematical Computational Modeling of Biofilms.

Date: 10/1/06 to 9/31/07

Co-PI: J. McLean

 

Agency: D.O.E. Laboratory Directed Research and Development

Title: Noninvasive Biofilm Characterization Utilizing Acoustic Microscopy

Date: 10/02/04-8/30/06

Co-PI: J. McLean

 

Funded Grants as Co-Investigator

  1. (Prlic, PI Prime; Dixon, PI Subcontract) 4/1/2018-3/31/2020

NIH

The Effect of Perio-implantitis on Innate-like T cell Function and Anti-bacterial Immunity

This study will help determine if a newly identified, T cell population (MAIT cells) that have been isolated from peri-implant tissues, are hyper or hypo-functional.

 

  1. 1R21DE026338-01 (Contact PI/Darveau, Coats, MPI) 7/1/2016-6/30/2018

NIH/NIDCR

Genetic basis for divergent virulence of P. gingivalis strains 33277 and 381

 

  1. 1R21DE026344-01 (Contact PI/Darveau, Jain, MPI) 9/1/2016-8/31/2018

NIH/NIDCR

Identification of the gene encoding lipid A deacylase, an enzyme required for TLR4-evasion, in Porphyromonas gingivalis

 

  1. 1631146 (Seibel)                                                9/1/2016-8/31/2019

NSF

PFI:BIC – Smart Laser-Based Imaging and Optical Spectroscopy System: optical quantification of bacterial load, oral health surveillance, and caries predication