Active Support
Domestication and Characterization of TM7-The Most Elusive Oral Phylum
NIH/NIDCR
The major goal of this project is to study the ecology, evolution and pathogenesis of human oral phlyum TM7 (Saccharibacteria) that our group has cultivated. The Saccharibacteria are now recognized as part of the Candidate Phyla Radiation and our cultivated strain TM7x was the first and only member of this large group that comprises nearly 25% of the diversity in the Domain Bacteria.
Making a Quantum Leap in Plaque Research with Modern Sciences
NIH/NIDCR
The major goals of this project are the development of new tools to study the etiology of dental caries, explore approaches for targeted elimination of cariogenic species and examine the effect on acid-production of the dental biofilm community.
Studying the Protective Effects of Normal Oral Flora
NIH/NIDCR
The major goal of this project is to study how normal flora can work together in a coordinated manner to prevent harmful ones from establishing themselves in our body.
Systematic Approach to Explore the Microbial Interactome
NIH/NIDCR
Research in this grant will seek to provide a versatile approach for comprehensive investigation of the microbial interactome.
Completed Support
Moving Beyond Diversity by Revealing Biological Functions of Uncultured Bacteria
NIH/NIGMS
We will investigate oral microbiome communities seeking to identify the species and genes that are highly correlated with microbial processes in disease state through parallel metabolomics and metatranscriptomics.
Award Details
Active As PI :
- Agency: NIH R01, National Institute of Dental and Craniofacial Research
Title: Domestication and characterization of TM7-the most elusive oral phylum
Date: 04/01/2014 – 12/31/23
PI: Jeffrey S. McLean (Multiple PI Award)
- Agency: NIH R01, National Institute of Dental and Craniofacial Research
Title: Making a Quantum Leap in Plaque Research with Modern Sciences
Date: 5/1/2010-12/31/2020
PI: Jeffrey S. McLean (Multiple PI Award)
- Agency: NIH R01, National Institute of Dental and Craniofacial Research
Title: Exploring the Protective Effects of Normal Oral Flora Against Foreign Pathogens
Date: 7/1/2016-6/30/2021
PI: Jeffrey S. McLean (Multiple PI Award)
- Agency: NIH R01, National Institute of Dental and Craniofacial Research
Title: 1R21DE027199-01 Systematic Approach to Explore the Microbial Interactome
Date: 7/1/2017-6/30/2019
PI: Jeffrey S McLean (Multiple PI Award)
Completed Grants:
Completed
Funded Grants as PI
Agency: NIH R01, National Institute of General Medical Sciences
Title: Moving Beyond Diversity by Revealing Biological Functions of Uncultured Bacteria
Date: 12/01/10-11/30/14 (NCE 2016)
PI: Jeffrey S. McLean
Agency: D.O.E.
Title: Microscale Metabolic, Redox and Abiotic Reactions in Hanford 300 Area Subsurface Sediments
Date: 05/15/08-05/14/12
PI: Haluk Beyenal (WSU)
Co-PIs: Jeffrey S. McLean (PNNL) and Jim K. Fredrickson (PNNL)
Agency: NIH R21, National Institute of Dental and Craniofacial Research
Title: Combined NMR/Optical Microscopy for Oral Biofilm Physiology Studies
Date: 05/15/07-05/14/10
PI: Paul Majors (PNNL)
Co-PI: Jeffrey S. McLean (PNNL)
Agency: D.O.E. OBER’s Genomics:GTL Program
Title: Integrated Genome-Based Studies of Shewanella Ecophysiology
Date: 9/31/06- 9/31/09
PI: J.Fredrickson
Co-PIs: Jeffrey S. McLean (PNNL), 10+ others
Agency: D.O.E. Laboratory Directed Research and Development
Title: Controlled Cultivation, Molecular Biology, and Advanced Imaging of Microbial Biofilms
Date: 10/1/04 to 9/31/07
PI: J. McLean
Agency: D.O.E. Laboratory Directed Research and Development
Title: Interrogation of Glucose Metabolism by Oral Biofilms Using Combined NMR/Optical Spectroscopy and Stable Isotope Labeling
Date: 10/1/05 to 9/31/07
Co-PI: J. McLean
Agency: D.O.E. Laboratory Directed Research and Development
Title: PNNL Metabolomics Measurement and Validation Development for Renewable Energy
Date: 10/1/05 to 9/31/07
Co-PI: J. McLean
Agency: D.O.E. Laboratory Directed Research and Development
Title: In Situ Magnetic Resonance Investigations of Metabolism and Mass Transport in Biofilms
Date: 10/1/04 to 9/31/05
Co-PI: J. McLean
Agency: D.O.E. Laboratory Directed Research and Development
Title: Mathematical Computational Modeling of Biofilms.
Date: 10/1/06 to 9/31/07
Co-PI: J. McLean
Agency: D.O.E. Laboratory Directed Research and Development
Title: Noninvasive Biofilm Characterization Utilizing Acoustic Microscopy
Date: 10/02/04-8/30/06
Co-PI: J. McLean
Funded Grants as Co-Investigator
- (Prlic, PI Prime; Dixon, PI Subcontract) 4/1/2018-3/31/2020
NIH
The Effect of Perio-implantitis on Innate-like T cell Function and Anti-bacterial Immunity
This study will help determine if a newly identified, T cell population (MAIT cells) that have been isolated from peri-implant tissues, are hyper or hypo-functional.
- 1R21DE026338-01 (Contact PI/Darveau, Coats, MPI) 7/1/2016-6/30/2018
NIH/NIDCR
Genetic basis for divergent virulence of P. gingivalis strains 33277 and 381
- 1R21DE026344-01 (Contact PI/Darveau, Jain, MPI) 9/1/2016-8/31/2018
NIH/NIDCR
Identification of the gene encoding lipid A deacylase, an enzyme required for TLR4-evasion, in Porphyromonas gingivalis
- 1631146 (Seibel) 9/1/2016-8/31/2019
NSF
PFI:BIC – Smart Laser-Based Imaging and Optical Spectroscopy System: optical quantification of bacterial load, oral health surveillance, and caries predication